Proteomics analysis of suckling mouse brain infected with attenuated rabies virus strain SRV9
نویسندگان
چکیده
منابع مشابه
Purified rabies vaccine (suckling rat brain origin).
A 10% suckling rat brain rabies vaccine free from encephalitogenic activity was prepared and inactivated with 1:8,000 beta-propiolactone (BPL), or ultraviolet light, or a combination of ultraviolet light and BPL, or 1% phenol. Potency was excellent in all samples, with the exception of the phenolized product which was marginal. A purified suckling rat brain (SRB) vaccine prepared by zonal centr...
متن کاملShort duration of neutralizing antibody titers after pre-exposure rabies vaccination with suckling mouse brain vaccine.
The human anti-rabies pre-exposure treatment currently used in Brazil, employing a 1-ml dose of suckling mouse brain vaccine (SMBV) administered on days 0, 2, 4 and 28, was compared to an alternative treatment with two 1 ml-doses on day 0, and one 1 ml-dose injected on days 7 and 21. The latter induced higher virus-neutralizing antibody (VNA) titers on day 21. Both Brazilian rabies vaccines pro...
متن کاملAutophagy is highly targeted among host comparative proteomes during infection with different virulent RABV strains
Rabies virus (RABV) is a neurotropic virus that causes serious disease in humans and animals worldwide. It has been reported that different RABV strains can result in divergent prognoses in animal model. To identify host factors that affect different infection processes, a kinetic analysis of host proteome alterations in mouse brains infected with different virulent RABV strains was performed u...
متن کاملProkaryotic Expression, Purification, and Polyclonal Antibody Production of a Truncated Recombinant Rabies Virus L Protein
Background: Rabies virus (RABV) is a deadly neurotropic virus that causes the disease of rabies in humans and animals. L protein is one of the large structural protein of rabies virus, which displays multiple enzymatic activities, and is required for viral transcription and replication. Objectives: A truncated L protein of Rabies virus is being cloned, expressed and purified to produce relevant...
متن کاملStability of rabies suckling mouse brain vaccine stored at different temperatures.
Rabies in man and animals continues to be a serious problem for public health and the livestock economy in most countries of Latin America and the Caribbean (I). Between 1980 and 1985 this area had a total of 1,744 registered rabies cases in humans, 83,858 in dogs, 6,876 in cats, and 28,800 in cattlealthough a considerable share of the bovine cases are usually not reported (2). According to dat...
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ژورنال
عنوان ژورنال: Acta virologica
سال: 2019
ISSN: 1336-2305
DOI: 10.4149/av_2019_406